NCCN Recommends ctDNA-MRD Testing Using Signatera™ Technology in Landmark Bladder Cancer Guideline Update
The National Comprehensive Cancer Network (NCCN) has updated its bladder cancer guidelines to include tumor-informed multiplex PCR circulating tumor DNA (ctDNA)-based molecular residual disease (MRD) testing using Signatera™ technology for patients with muscle-invasive bladder cancer (MIBC). This marks a significant development, as it allows for risk stratification and guides the use of adjuvant immunotherapy post-cystectomy, earning a Category 1 recommendation for Signatera-guided treatment. The update is based on strong evidentiary support, including the landmark IMvigor011 trial, and is expected to influence broader MRD-guided cancer care.
https://www.businesswire.com/news/home/20260623843077/en/NCCN-Recommends-ctDNA-MRD-Testing-Using-Signatera-Technology-in-Landmark-Bladder-Cancer-Guideline-Update