Natera (NASDAQ: NTRA) PALLAS: Signatera MRD‑positive group shows 13.4‑21.5 hazard ratios
Natera, Inc. announced initial results from the Phase III PALLAS study, showing that its Signatera molecular residual disease (MRD) test provides powerful post-surgical prognostic information for patients with high and intermediate risk HR+/HER2- breast cancer. The study found that MRD-positive patients had significantly worse outcomes and substantially elevated hazard ratios for distant recurrence compared to MRD-negative patients, supporting the integration of MRD testing into routine post-surgical risk assessment. These findings indicate a potential shift towards personalized treatment strategies, where MRD status could guide the intensity and type of therapy.
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