BioMarin’s (BMRN) Phase 3 Trial of BMN 401 for ENPP1 Deficiency Meets One Co-Primary Endpoint
BioMarin Pharmaceutical Inc. (BMRN) announced that its Phase 3 ENERGY 3 trial for BMN 401 in children with ENPP1 deficiency met only one of its two co-primary endpoints. While treatment significantly increased plasma inorganic pyrophosphate concentration, it failed to improve critical measures of rickets severity or other secondary endpoints. The company is evaluating the data to determine next steps, expressing disappointment that increased PPi levels did not translate into clinical benefits.
https://ca.finance.yahoo.com/news/biomarin-bmrn-phase-3-trial-132921475.html