Astrazeneca PLC ($AZN) Stock Forecast: Down 0.8% Today

What is Astrazeneca PLC?

AstraZeneca PLC (AZN) Market AstraZeneca PLC is a multinational pharmaceutical company known for its innovative drugs in various therapeutic areas. The overall market for pharmaceuticals has been volatile recently due to regulatory changes, patent expirations, and intense competition among major players.

Why is Astrazeneca PLC going down?

AZN stock is down 0.8% on Oct 28, 2025 15:55

• AstraZeneca's stock experienced a strong bearish movement recently.
• The decrease in short interest by 28.0% indicates reduced speculation on the stock's decline, potentially signaling a lack of confidence in its short-term performance.
• Investors might be reacting to concerns about the company's upcoming earnings or potential setbacks in its drug development pipeline, leading to the negative market sentiment.
• The focus on another company's oncology drugs and their growth prospects could have diverted investor attention away from AstraZeneca, contributing to the bearish movement in its stock price.

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Here's How Eli Lilly's Oncology Drugs Are Poised Ahead of Q3 Earnings

LLY's oncology portfolio, led by Verzenio, is set for double-digit growth as investors eye Q3 results beyond its obesity drugs.

https://www.zacks.com/stock/news/2776275/heres-how-eli-lillys-oncology-drugs-are-poised-ahead-of-q3-earnings

Peering Into AstraZeneca PLC's Recent Short Interest - AstraZeneca ( NASDAQ:AZN )

AstraZeneca PLC's ( NYSE:AZN ) short interest as a percent of float has fallen 28.0% since its last report. According to exchange reported data, there are now 5.46 million shares sold short, which is 0.18% of all regular shares that are available for trading.

https://www.benzinga.com/insights/short-sellers/25/10/48353573/peering-into-astrazeneca-plcs-recent-short-interest

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Astrazeneca PLC Price History

28.09.2025 - AZN Stock was down 0.8%

• AstraZeneca's stock experienced a strong bearish movement recently.
• The decrease in short interest by 28.0% indicates reduced speculation on the stock's decline, potentially signaling a lack of confidence in its short-term performance.
• Investors might be reacting to concerns about the company's upcoming earnings or potential setbacks in its drug development pipeline, leading to the negative market sentiment.
• The focus on another company's oncology drugs and their growth prospects could have diverted investor attention away from AstraZeneca, contributing to the bearish movement in its stock price.

30.04.2025 - AZN Stock was up 3.2%

• AstraZeneca's stock saw a notable increase following the approval of Imfinzi by the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) for use in muscle-invasive bladder cancer. This approval is a significant milestone for the company, enhancing investor confidence in its oncology portfolio.
• The regulatory decision was supported by promising results from the phase III NIAGARA study, showcasing the effectiveness and safety of Imfinzi in combination therapy. The release of this positive data likely contributed to the surge in investor optimism and the subsequent rise in stock price.
• The market's positive response reflects confidence in AstraZeneca's ability to deliver innovative treatments to patients and solidifies its position in the pharmaceutical industry. This regulatory approval is expected to attract more investor attention to AZN stock.

30.09.2024 - AZN Stock was down 5.3%

• AstraZeneca's stock had a bearish movement despite the positive news of an exclusive worldwide license agreement with Monopar Therapeutics for ALXN-1840 to potentially treat Wilson disease.
• The market may have reacted negatively due to broader economic concerns impacting the pharmaceutical sector or profit-taking after a recent surge in the stock price.
• Investors might be cautious about the long-term implications of the agreement and its potential impact on AstraZeneca's financials.

03.06.2025 - AZN Stock was down 1.3%

• Despite the positive performance of AstraZeneca in the latest trading session, the overall market sentiment towards the stock was bearish, resulting in a notable decrease in its value.
• The decline in AstraZeneca's stock price could be attributed to investors' concerns about the company's long-term growth prospects, as indicated by the downward trend over the past month and year.
• The information about Pfizer's strong late-stage pipeline and potential for long-term growth may have inadvertently shifted investor attention away from AstraZeneca, impacting its stock performance negatively.
• Investors may be reevaluating AstraZeneca's price-to-earnings ratio in light of the recent market movements and industry developments, leading to a more cautious outlook on the stock.

09.03.2025 - AZN Stock was down 7.7%

• The EU approval for expanded use of two separate cancer drugs by Astrazeneca did not seem to have a positive impact on the stock price, as it closed lower.
• Despite the positive news of Enhertu reducing the risk of disease progression in breast cancer patients and the expanded label for Imfinzi in lung cancer, investors may have been expecting even more significant developments.
• The market's reaction could indicate that investors were possibly concerned about other factors such as competition in the cancer drug market or overall market conditions, leading to the bearish movement in Astrazeneca's stock.

05.10.2024 - AZN Stock was down 6.6%

• Despite the positive unveiling of early data from a weight loss drug partnership, AstraZeneca's stock experienced a bearish movement.
• The bullish stance taken by smart money in AZN options indicates a positive outlook, but the market movement suggests otherwise.
• It is possible that the market was expecting more substantial results or developments from the weight loss drug data, leading to disappointment and a bearish trend in the stock price.
• Investors may have been anticipating a stronger performance from AstraZeneca compared to the market, resulting in the stock trailing behind despite the positive data shared at the ObesityWeek 2024 event.

05.10.2024 - AZN Stock was down 6.6%

• Smart money investors have taken a bullish stance on AstraZeneca, as seen in the options market, but this did not translate into a positive movement in the stock price today.
• AstraZeneca unveiled early data from a Chinese-firm partnered oral weight loss drug, which could have generated mixed reactions from investors leading to the bearish movement.
• Despite a slight rise in the stock price, AstraZeneca still trailed the overall market, indicating that the news about the weight loss drug may not have been enough to offset other negative factors impacting the stock.

05.10.2024 - AZN Stock was down 7.1%

• The detention of current and former employees by Chinese authorities for alleged illegal activities in the pharmaceutical sector could have raised concerns among investors, leading to a bearish sentiment.
• Despite the positive unveiling of early data from a partnered oral weight loss drug, the overshadowing negative news regarding the investigation into potential data privacy law breaches might have impacted the stock negatively.
• The bullish stance taken by smart money in AZN options might not have been enough to counterbalance the negative sentiment stemming from the legal issues, resulting in the bearish movement.
• While the stock closed slightly higher in the most recent trading session, it still trailed the overall market performance, indicating that the concerns surrounding the investigation might be weighing down on investor confidence.

06.01.2025 - AZN Stock was up 5.9%

• AstraZeneca reported strong Q4 earnings with revenue exceeding expectations, particularly driven by higher sales in oncology and respiratory drugs.
• Despite facing potential fines in China, the company's positive financial outlook for FY25, projecting revenue growth and EPS growth, boosted investor confidence.
• The multiple class action lawsuits against AstraZeneca seem to have had minimal impact on the stock price, indicating that investors are more focused on the company's operational performance and future prospects.
• Overall, the bullish movement in AstraZeneca's stock today can be attributed to the robust Q4 earnings report and optimistic guidance for the future, outweighing any legal challenges the company currently faces.

04.03.2025 - AZN Stock was down 5.1%

• The partnership with OncoHelix to provide liquid biopsy testing for prostate cancer patients could be seen as a positive development, but the market may have already priced in this event.
• The FDA approval for Imfinzi's expanded use in bladder cancer indicates the company's commitment to advancing its oncology portfolio, which should have been a positive catalyst.
• Despite the positive developments, the market might have reacted bearishly due to concerns about competition in the oncology space or broader market conditions impacting pharmaceutical stocks.
• Investors may be uncertain about the potential market impact of the FDA approvals on AstraZeneca's revenue and profitability, leading to a cautious outlook and the bearish movement in the stock price.

04.03.2025 - AZN Stock was down 7.7%

• AstraZeneca received multiple approvals for its flagship cancer drugs and expanded indications for Imfinzi in bladder cancer, showcasing the company's commitment to developing cutting-edge treatments.
• Despite the positive developments on drug approvals and partnerships, the market reaction suggests that investors may have been expecting even more significant progress or revenue projections.
• The milestone payment owed to Daiichi Sankyo and the partnership with OncoHelix could indicate increased expenses or investments in research and development, potentially affecting short-term profitability and stock performance.
• There is uncertainty about the market's next move, which may have contributed to the bearish trend as investors exercise caution regarding the company's future growth prospects in the competitive pharmaceutical industry.

01.09.2025 - AZN Stock was up 9.3%

• AstraZeneca's recommendation for a Harmonized Listing Structure across multiple stock exchanges may have boosted investor confidence and attracted more shareholders, contributing to the bullish movement.
• The launch of AstraZeneca Direct, offering discounted prices for prescribed medications through an online platform, could have been perceived positively by investors, driving up the stock price.
• The FDA's priority review for AstraZeneca and Daiichi's Enhertu in breast cancer, based on promising phase III data, likely added to the positive sentiment surrounding AstraZeneca's stock.
• Despite a recent decline in stock price, the overall market movement today suggests that investors are focusing more on the company's strategic initiatives and potential growth opportunities, leading to the bullish trend in AstraZeneca's stock.